Nicotinamide adenine dinucleotide, more commonly known as NAD+, is a vital coenzyme found in every living cell in the human body. Its primary role is to facilitate the transfer of electrons during metabolic reactions—a process that allows your cells to convert the food you eat into usable energy. Without NAD+, this energy transfer would grind to a halt, and life as we know it would not be possible. In many ways, NAD+ functions as a foundational molecule that quietly powers nearly every biological process that keeps us alive and functioning.

The human body is made up of approximately 37.2 trillion cells, each carrying out specialized tasks to support overall health. While these cells differ in function—whether in the brain, muscles, skin, or organs—they all share one essential requirement: energy. This energy is produced inside cellular structures called mitochondria, often referred to as the “power plants” of the cell. Mitochondria are responsible for maintaining metabolic balance, repairing cellular damage, and sustaining the functions that keep tissues healthy. NAD+ plays a central role in enabling mitochondria to perform these critical tasks efficiently.

Mitochondrial health is closely linked to how we age. In fact, mitochondrial dysfunction is considered one of the hallmark features of aging. Mitochondria generate roughly 90% of the body’s energy by converting nutrients into adenosine triphosphate (ATP), the molecule that fuels cellular activity. This energy production depends on a steady supply of NAD+. When NAD+ levels are optimal, cells are better equipped to maintain energy output, adapt to stress, and repair damage. When NAD+ declines, mitochondrial efficiency drops, and cellular performance begins to suffer.

Unfortunately, NAD+ levels naturally decline with age—by as much as 65% between the ages of 30 and 70. This decline is driven by several factors, including increased oxidative stress, chronic inflammation, reduced efficiency in NAD+ recycling, and higher demands for cellular repair. As NAD+ becomes depleted, essential proteins such as sirtuins and PARPs struggle to function properly. These proteins help regulate cellular balance, repair DNA damage, and maintain genomic stability. When their activity is impaired, energy metabolism slows, cellular resilience weakens, and the biological processes associated with aging accelerate.

NAD+ is therefore essential not only for energy production, but also for cellular repair and regeneration. It activates sirtuins, which help regulate metabolism, stress resistance, and cellular longevity, and it fuels PARPs, enzymes that repair DNA damage caused by oxidative and environmental stress. As we age, the body also produces fewer mitochondria, placing greater strain on the ones that remain and further accelerating the aging process. While this decline is natural, it is not inevitable. Supporting mitochondrial health—and replenishing NAD+ levels—offers a powerful way to help maintain cellular function, resilience, and vitality as we age.

While NAD+ is essential for cellular energy and longevity, not all NAD+-boosting approaches are created equal. Most existing supplements rely on precursors such as NR or NMN, which must first be broken down during digestion and then converted through multiple steps before the body can synthesize usable NAD+. This process is inherently inefficient—only a small fraction of oral supplements survive absorption intact, and even fewer reach cells in a form the body can readily use. RiaGev®-WS™ was developed to solve this problem by going straight to the source. It is a patented, proprietary formulation that uniquely combines Bioenergy Ribose® and nicotinamide ascorbate, a stable form of vitamin B3, delivered in their free form and pre-balanced in an ideal performance ratio. By entering the NAD+ salvage pathway directly—where up to 90% of NAD+ conversion occurs—RiaGev-WS™ bypasses unnecessary breakdown steps and delivers superior bioavailability compared to traditional precursors.

The pharmacodynamics of RiaGev-WS™ demonstrate it to be more efficient than NR at increasing NAD+ levels throughout the body, including muscle and brain tissue. Unlike many products that focus solely on boosting energy output, RiaGev was developed with the goal of supporting metabolic balance while enhancing energy—promoting ATP production while helping manage the cellular stress that often accompanies increased energy demand. Clinical research shows that RiaGev-WS™ not only raises NAD+, but also significantly increases the broader NAD+ metabolome, including NADP+ and NADPH, molecules critical for antioxidant cycling and glutathione regeneration. By safely enhancing the NAD+ salvage pathway and improving NAD+ utilization across all tissues, RiaGev-WS™ supports mitochondrial function at its foundation—helping sustain long-term energy production and promote healthy aging from the inside out.*

Grail Eternal NAD+ Booster is formulated with the highest concentration of Bioenergy RiaGev®-WS™ available today, designed to support sustained NAD+ production at the cellular level where aging begins. When combined with regular exercise and a nutrient-dense, healthy diet, restoring NAD+ levels can help promote greater energy, resilience, and long-term vitality. By supporting mitochondrial function and the body’s natural repair systems, Grail Eternal offers a science-backed approach to healthy aging—helping slow the effects of time and maintain a more vibrant, active life from the inside out.*